|Title||Down syndrome in births near landfill sites.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Jarup L, Morris S, Richardson S, Briggs D, Cobley N, de Hoogh C, Gorog K, Elliott P|
|Date Published||2007 Dec|
|Keywords||Adult, Case-Control Studies, Down Syndrome, England, Environmental Exposure, Female, Hazardous Waste, Humans, Infant, Male, Pregnancy, Prenatal Exposure Delayed Effects, Refuse Disposal, Registries, Residence Characteristics, Retrospective Studies, Risk Assessment, Topography, Medical, Wales|
OBJECTIVES: The aim of the study was to examine the risk of giving birth to a child with Down syndrome associated with residence near landfill sites in England and Wales.
METHODS: A 2-km zone around 6289 landfill sites processing special (hazardous), non-special and unknown waste type was used to indicate exposure. Postcodes within the 2-km zone were classified as 'exposed' and people living beyond 2 km comprised the reference population. Health outcome data were Down syndrome registrations from a national registry including 21 cytogenetic laboratories in England and Wales, for the years 1989 to 1998. With a Bayesian regression model, we calculated relative risks for the population living within 2 km of landfill sites relative to the reference population, assuming a common relative risk for all landfill sites. Adjustments were made for major confounders.
RESULTS: There were 4640 cases of Down syndrome within 2 km of a landfill site. We found no excess risks of Down syndrome related to landfill sites. Adjustment for socio-economic status (SES) did not influence our estimates. There were no differences in risk between hazardous waste sites and other landfill sites.
CONCLUSION: We found no excess risk of Down syndrome in populations living near landfill sites.
|Alternate Journal||Prenat. Diagn.|